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Hepatocytes could also dedifferentiate into hepatic progenitor cells (HPCs, which are identified by markers such as SMA, SOX9, KRT19, EpCAM, and PROM1), and the proliferation and differentiation of hepatocyte-derived HPCs are closely associated with ductular reactions and portal fibrosis in liver injury (101)

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The most common outcome reported that BTK and other TEC family genes havent been directly linked to RA through genetic studies, but pathway analyses show they are involved in key disease processes [88]

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