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Also, when blood-brain barrier (BBB) is disrupted by stroke and other brain diseases, it helps to transfer the systemic iron pool into neurons in the brain parenchyma, exacerbating ferroptosis (DeGregorio-Rocasolano et al., 2019)

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These pathways can provide important compensation when GPX4 is partially impaired, also indicating that ferroptosis regulation has high redundancy, and single-target intervention may not completely block the pathological process

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PMID 24475799

MMC motility restoration to prevent recurrence via serotonin pathway support (SIBO-MMC)*