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This allows the creatine to be more efficiently transported to muscle cells, where it plays a critical role in the rapid regeneration of ATPthe primary energy source for muscle contractions during intense exercise

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Because of the key sex differences in the effect of ES [240,241,242,243] and nutrition [244] and general metabolisms [245] and disease prevalence and presentation [238, 239], it is key for future studies to consider both sexes when assessing efficacy of nutritional interventions in ES research and to include sex as a discovery variable

doi: 10.1136/jnnp.2003.025858 40