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The heterogeneity in animal species, strain, and age adds variability that complicates cross-study comparisons (Spears et al

[84] Hamilton-Reeves J, Rebello S, Thomas W, et al

To compensate for this, several normalization methods can be applied, including adjustments based on creatinine levels, specific gravity, conductivity, osmolality, or collecting 24-hour urine (Lermen et al

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