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Methods: A comprehensive search was conducted across PubMed, Scopus, and Embase up to July 2024

10.1016/s0165-0173(01)00054-6 25 DawudiY.AzoyanL.BrouckerT

This two-pronged attack is much more effective than either alone

Epilepsia 32 , 798809 (1991)

Especially short (less than 21 days) or long (35 days or more) menstrual cycles, irregular cycles, or absence of periods may be symptoms of reduced fertility

Notably, TMAO also amplifies ERS markers such as heat shock protein 60 and glucose regulated protein 78kD in macrophages, correlating with elevated toll-like receptor 4 expression and proinflammatory cytokine production (e.g., TNF-, IL-6) (88, 89)