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Bile acid homeostasis requires normal terminal ileum function to absorb bile acids for recirculation (enterohepatic circulation)

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Understanding that purging is normal (and often a sign the treatment is working) helps users push through this uncomfortable phase rather than abandoning treatment prematurely

The resin is functionalized with an acid labile linker that allows for acidic cleavage usually trifluoroacetic acid, hydrofluoric acid (HF) or trifluoromethanesulfonic acid