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1 H NMR (300 MHz, DMSO) 8.26 (d, J = 7.6 Hz, 1H), 7.45 7.34 (m, 9H), 7.25 (d, J = 1.4 Hz, 1H), 7.13 7.03 (m, 6H), 7.03 6.95 (m, 1H), 6.70 6.61 (m, 1H), 4.49 (q, J = 6.9 Hz, 1H), 3.54 (s, 3H), 3.52 (d, J = 5.9 Hz, 1H), 2.82 (dd, J = 6.7, 3.4 Hz, 2H), 1.35 (s, 9H)

The complete reconstitution guide walks through each step

2016;4:e12885

Although these findings were observed in non-CRC models, they are highly relevant to CRC, where hypoxia-driven chemoresistance remains a significant challenge (141)

Introduction Chronic kidney disease (CKD) is defined by abnormalities in kidney structure or function and is characterized by permanent nephron loss and an eventual decline in the glomerular filtration rate (GFR) (Zalups and Diamond, 1987)

Vitamin C: Often included to enhance the brightening effect and provide additional antioxidant support