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Current opinion in gastroenterology
Effects of tissue plasminogen activator on cerebral microvessels of rats during focal cerebral ischemia and reperfusion
These sustained-release formulations and delivery methods can be administered through either percutaneous endoscopic gastro-jejunostomy tubes or mini-pumps, and are designed to provide a more consistent and controlled release of L-DOPA over an extended period of time, thereby reducing the likelihood of non-physiological pulsatile striatal dopamine receptor stimulation and maladaptive neuronal responses [54]
Wang, J., Zhou, J., Cheng, C