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Nat Genet 47(12):1426-34, 2015

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Microvasculature changes and cerebral amyloid angiopathy in Alzheimers disease and their potential impact on therapy

First, optimal dosing in humans remains undefined, with current practice based primarily on extrapolation from animal studies and anecdotal clinical experience rather than formal dose-finding studies

This is then condensed by Arg1 with aspartate to form argininosuccinate which is then cleaved to fumarateone of the TCA cycle intermediates