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The nonoperative treatment of KOA mainly includes anti-inflammatory drugs and biologics, such as non-steroidal anti-inflammatory drugs (NSAIDs), hyaluronic acid, glucocorticoids, diacrine, and chondroitin sulfate [7]

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In rats, kefir consumption reduced blood glucose levels, improved oxidative stress management, and delayed the onset of diabetic nephropathy (Kahraman et al., 2021)

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