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du Plessis L1, Laubscher P, Jooste J, du Plessis J, Franken A, van Aarde N, Eloff F

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Thus, it is likely that with BPC 157 therapy, no extraosseous bone islet means the counteraction of the endochondral bone formation in extraskeletal tissues, the counteraction of vascular endothelial cells differentiation into skeletal cells, local inflammatory signals, and the release of cytokines (i.e., bone morphogenetic protein-2 and bone morphogenetic protein-4 and transforming growth factor-beta) [68]

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It also protects cancer cells from apoptosis by induction of anti-apoptotic proteins, such as BCL2, BCLxL, XIAP, and so on [60, 63, 64]