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Selenium is effective in low doses, and taking too much can be harmful

ERT is also potentially limited by reaccumulation of Gb3 in podocytes after dose adjustment during the follow-up period and formation of neutralizing antidrug antibodies after infusion, which reduce the efficacy of ERT by increasing cellular Gb3 deposition and results in harmful clinical outcomes that include progressive loss of renal function 13,14

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Some of the more common derivatives of cyclodextrin are hydroxypropyl ethers, sulfonates, and sulfoalkylethers

8d, e, neither astrocytic Drd2 conditional knockout nor pyridoxine treatment altered the toxic MPP + levels in the striatum