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Tsukaguchi, H

Recent studies have demonstrated that BBR can enhance the radiosensitivity of liver cancer by modulating the cell cycle and senescence pathways

The compound was developed by Peter de Keizer and colleagues at Erasmus University Medical Center (Rotterdam) and published in a landmark 2017 Cell paper (Baar et al., Cell 169:132-147) demonstrating selective induction of apoptosis in cellular senescence research models

ATP exposure stimulates glutathione efflux as a necessary switch for NLRP3 inflammasome activation

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