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(111) studied Huntingtons gene-mutant mice and found that EODF slowed disease progression, increased survival rates, improved motor performance, reduced brain atrophy, and decreased huntingtin aggregate formation and caspase activation, normalized glucose regulation, and restored BDNF and chaperone protein levels in the cortex and striatum compared to the AL group

In attempts to overcome BBB impermeability, purified neurotrophic factors were directly infused into the brain through intracerebroventricular (ICV) injection