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Gaertner DJ et al (1987): Muscle necrosis in Syrian hamsters resulting from intramuscular injections of ketamine and xylazine

So your core is totally engaged the entire time

And so its just the, you know, in a healthy person, this regulation is happening and its doing something positive by helping mitochondria only take on the burdens that they can handle, to be efficient burners of energy, to produce the cellular energy that makes you feel good

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Although FOXO4s specific effects on mitochondria are as direct as the other peptides above, it is known to regulate the expression of genes involved in oxidative stress response and energy metabolism, which can impact mitochondrial function indirectly (Liu, 2019)