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For example, a carbohydrate-based energy source results in decreased muscular pH owing to increased lactic acid production, which leads to impaired muscle contraction

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doi: 10.1039/D1TB00628B

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Conclusion A series linear Ang IV analogues demonstrating improved metabolic stability and very high affinity to IRAP have been reported, e.g., the potent hexapeptides 11 (AL-11) and 12 (IVDE77) with Ki values of 7.6 and 1.7 nM, respectively, data to be compared with the Ki value of Ang IV of 62 nM in the same binding assay