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The regulation of cell death plays a role in promoting or alleviating Cardio-Cerebrovascular Diseases

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It is known that pro-inflammatory cytokines play a significant role in the development of various autoimmune diseases

Cannabidiol induces intracellular calcium elevation and cytotoxicity in oligodendrocytes

For example, metformin, a firstline agent in PCOS for insulin resistance, has been shown in patients with type 2 diabetes to blunt NET formation: in vitro, metformin prevented chromatin decondensation and DNA release and in vivo reduced circulating NET biomarkers (e.g., dsDNA, citrullinated histone H3) independent of glucoselowering effects [93]