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Oxidative stress plays an important role in the pathogenesis of a variety of autoimmune diseases and many environmental agents participate in this process

Uptake of circulating insulin-like growth factors (IGFs) into cerebrospinal fluid appears to be independent of the IGF receptors as well as IGF-Binding proteins

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Bcl-2, B-cell lymphoma-2

In the brain, these oxidative modifications often cause the accumulation of misfolded proteins and aggregates [98,118,119]

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