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Differences in study duration and patient populations complicate direct comparison, but the mechanistic rationale and sheer magnitude of effect strongly favor Retatrutide for monotherapy applications

doi: 10.1111/cen.12524 178 ManciniALeoneESilvestriniAFestaRDi DonnaVDe MarinisLet al

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It does not cross the blood-brain barrier, but in the body, it can trigger panic symptoms such as racing/pounding heart, anxiety, nausea, sweating, insomnia, shortness of breath, shaking, etc

Thorpe A, Neal D