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Preparation of the Compound Mixture All components of the mixture were purchased from Sigma-Aldrich (Milan, Italy) and solutions were sterilized by 0.22 m filtration

Lastly, the melancholic profile is based on eight items of waking up too early, quality of mood, hypophagia, decreased weight, linkage of mood to time of day (if worse in the morning), view of self, psychomotor agitation and psychomotor retardation (range 024)

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