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10.1007/s11126-019-09666-9 304

Much of it is indirect, preclinical, observational, or focused on biomarkers rather than clinically meaningful outcomes [8][1012][1415]

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Possible concerns encompass herbdrug interactions (e.g., botanical substances influencing cytochrome P450 enzymes), ocular surface toxicity resulting from extended use of certain extracts or preservatives in formulations, and systemic adverse effects from oral supplementation

Hence, the EBV UTPase may act as a novel pathogen-associated molecular pattern (PAMP) ligand protein for TLR2 (132)