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Culture medium was replaced every 23 days over a 12-day period

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Author Contributions Conceptualisation, N.Y., P.W.R.H., J.W

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[33] An editorial published in the Journal of the American Medical Association said that "the study findings may provide novel hypotheses that merit further evaluation to help understand the pathophysiology of secondary prevention of vascular disease." [40] Critics of the study characterized it as showing no support for the use of chelation therapy in coronary heart disease, particularly the claims that chelation reduces the need for coronary bypass surgeries