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Their work showed that restoring MST1 expression activates p53, which subsequently phosphorylates Drp1 at Ser616 to facilitate mitochondrial fission while concurrently suppresses Parkin transcription (61)

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HUVEC cells were stained with 0.5 M Calcein-AM and the fluorescence was detected by fluorescence microscope, and quantitative analysis of each image was performed using Image J 1.53t software

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However, to many a surprise, the treatment did not result in meaningful decreases in the frequency of vaso-occlusive pain experienced by SCD patients