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There are many agents with a well known depigmenting effect like pycnogenol, orchid extract, marine algae extract, cinnamic acid, soy, aloesin, Boswellia , hydroquinone, glycolic acid, arbutin, kojic acid, ascorbate, tocopherol, niacinamide, etc

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The reference materials listed below are provided for background review of sterile research preparation standards, preservative-system context, reconstitution handling practices, and formulation specifications relevant to laboratory workflows

This is usually because it's feeding on certain oils or fatty acids