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Sorafenib upregulates ABCC5 via the PI3K/Akt/Nrf2 pathway, which inhibits lipid peroxidation-mediated ferroptosis and promotes cancer growth, resulting in acquired sorafenib resistance in human HCC cells, according to Huang et al (91)

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Mechanism 1: Mitochondrial Oxidative Stress EGCG at high concentrations generates reactive oxygen species (ROS) inside hepatocytes, a mechanism documented in multiple cell-culture and rodent studies [7]

If one line fails, the lab should follow its internal material-control rules rather than rely on assumption

Metformin attenuates Alzheimers disease-like neuropathology in obese, leptin-resistant mice