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Furthermore, the extract upregulated the expression of aquaporin 5 (AQP5) in the lacrimal glands and inhibited the activation of MAPK and NF-B signaling pathways, leading to decreased production of pro-inflammatory cytokines [89]

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Studies have shown that the decline in AMPK activity leads to an increase in lipid synthesis, obstruction of fatty acid oxidation, enhanced oxidative stress, and activation of inflammation, while natural products can restore energy metabolic homeostasis through the AMPK pathway

Clin Chim Acta 275 : 175184 Rennard SI, Basset G, Lecossier D, O'Donnell KM, Pinkston P, Martin PG, Crystal RG 1986 Estimation of volume of epithelial lining fluid recovered by lavage using urea as marker of dilution

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Cafestol, a bioactive substance in coffee, has antidiabetic properties in KKAy mice