2 Ferroptosis and its link to DCM Ferroptosis is a form of programmed cell death driven by the excessive accumulation of iron ions within cells, triggering the Fenton reaction, activating oxidative stress, and disrupting lipid metabolism, ultimately leading to cellular demise (22, 23)
Age-related disturbances in glutathione reductase activity have been also reported (59), and an increasing frequency of glutathione transferase GSTT1 homozygous deletions is also associated with age (7, 22, 68-70)
Higgins et al., 2002
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Heavy drinkers face amplified risk because chronic alcohol use keeps CYP2E1 activity permanently heightened
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