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This finding suggests that Sertoli cell dysfunction, as reflected by anti-Mllerian hormone production, may play a role in maintaining chromatin stability during spermiogenesis. Other hormones, including follicle-stimulating hormone, luteinising hormone, oestradiol, inhibin B, and thyroid-stimulating hormone, did not show associations with semen parameters or DNA fragmentation

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Uncertainty of the estimates The paucity and (inevitable) inconsistency of the available data is sufficient to see that we cannot quantify the pregnancy outcomes risk from smoke-free nicotine and tobacco product use