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doi: 10.5344/ajev.1970.21.4.189 22 ComitiniF.GobbiM.DomizioP.RomaniC.LencioniL.MannazzuI.et al

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A foundational study by Ostrovskaya and Gudasheva found that chronic 28-day administration of Noopept increased both BDNF and NGF mRNA levels in the hippocampus without tolerance development

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Besides, several exogenous factors have been shown to activate EAAT3, primarily by influencing NF-B signaling, which subsequently upregulates EAAT3 expression