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Long-term metformin use is recognized by regulators as being associated with reduced B12 levels in some patients, which is one reason clinicians may monitor B12 status over time - and one reason injectable B12 delivery may be particularly relevant for long-term metformin users

Extra vitamin B12 can be stored in the liver, and only small amounts are lost through your urine, sweat, or stools each day

Most of us can get a sufficient amount of vitamin B12 purely through diet, but there are some cases where dietary restrictions make consuming the vitamin through food incredibly difficult, or where the body is not able to absorb the amount of vitamin B12 that it requires

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