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Experiments on immature laboratory animals (dogs, rabbits, and rats) have shown that FQs cause cartilage damage by inducing necrosis of chondrocytes (36 hours after treatment), disruption of the extracellular matrix, and formation of vesicles and fissures at the articular surface

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pombe the first step is catalyzed by Egt1 leading to hercynylcysteine sulphoxide formation 16,17

(1) Brcic L, Brcic I, Staresinic M, Novinscak T, Sikiric P, Seiwerth S

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Most without informing their prescribing physician