Nutritional supplementation with l-carnitine could mitigate these pathobiological processes by inhibiting NF-B and down-regulating NOX1/NOX2, thereby enhance the antioxidant effects of angiotensin II 636
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This bidirectional behavior highlights a critical context dependence in antioxidant biology, where the same metabolite may either suppress or amplify ferroptotic stress depending on iron availability and intracellular redox flux
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The work described in this publication benefited from the support of the Metabolomics Shared Resource and of the Biobank Shared Resources (BSR) at the Wilmot Cancer Institute, supported in part by a University of Rochester Wilmot Cancer Institute Support Grant (P30CA272302)
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