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NAPQI targets hepatocyte mitochondrial proteins for adduct formation, causing mitochondrial dysfunction which plays a central role in AILI [37]

Cancer Res Treat (2018) 50(2):44560

This allows you an extra way to get glutathione into your body and thyroid gland to reduce thyroid gland inflammation and damage

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Interestingly, as for BRCA1, p62 expression is regulated by NRF2, due to the presence of ARE sequences in the p62 promoter, implying a positive-feedback loop [199]