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Overall, these findings suggest that ATXN3 aggregation may target directly or indirectly a metastable subproteome, thereby causing an increased susceptibility to multifactorial toxicity and, eventually, the collapse of many essential cellular functions, and this may help to explain the phenotypic complexities displayed in SCA3

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Convenience is higher, but penetration and systemic effects are limited

Inter-assay variations were higher than those declared by the manufacturers with only one exception which also had the best overall performance

Panico, C