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In this setting, CYP2A6 metabolism and conversion of nicotine to its metabolites is unlikely and consequently high metabolite concentrations, typically reported in humans, were not observed

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Finally, Riggs and colleagues (2007) evaluated the relationship between adolescent trajectories of tobacco use and nicotine dependence in early adulthood and found that adolescents who demonstrated early stable use of tobacco (two cigarettes per week by 12 years of age) were more likely to have greater nicotine dependence as young adults

Bitzer, S.M

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