Oxford University Press, Oxford, UK
As TP53 mutations are strong drivers of negative outcomes in multiple hematologic malignancies, as exemplified by relapsed pediatric acute lymphoblastic leukemia, APR-246 may likely have more broad clinical implications including synergy with traditional cytotoxic agents, as has been recently described.20 Together, shedding light on the synergistic mechanisms underlying APR-246 and azacitidine therapy as presented in this study are critical to continue to advance this novel therapeutic option for patients with the poorest outcomes to traditional treatments
Because the condition is asymptomatic, it often goes undiagnosed until a couple seeks medical advice after trying to get pregnant for an extended period without success
Analysis of the chromosome X exome in patients with autism spectrum disorders identified novel candidate genes, including TMLHE
A loading phase of 1mg three times weekly for two weeks, then maintenance of 1mg every two to three months, adjusted for the cause and any neurological involvement
Inhibition of ferroptosis ameliorates hypertensive nephropathy through P53/nrf2/P21 pathway by taohongsiwu decoction: based on network pharmacology and experimental validation
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