According to the TCGA database, The expression levels of SLC7A11 mRNA in Cervical cancer (CESC), Cholangiocarcinoma (CHOL), Colonic adenocarcinoma (COAD), Esophagus cancer (ESCA), Head and neck squamous cell carcinoma (HNSC), chromophobe kidney cell carcinoma (KICH), Clear cell carcinoma of kidney (KIRC), Papillary cell carcinoma of the kidney (KIRP), Liver cell carcinoma (LIHC), Lung adenocarcinoma (LUAD), Squamous cell carcinoma of the lung (LUSC), Adenocarcinoma of the pancreas (PAAD), Rectum adenocarcinoma (READ), Sarcoma (SARC), Cutaneous melanoma (SKCM), Stomach adenocarcinoma (STAD), and Endometrial carcinoma of the flesh (UCEC) were significantly higher than those in adjacent normal tissues
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The authors concluded that GHK acts by affecting TGF-1/Smad 2/3 and IGF-1 pathway
showed that the core clock gene BMAL1 regulates EC proliferation by modulating cell-cycle regulators, particularly cyclin D1 (58)
8 , 328rv324328rv324 (2016)
