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These provide additional tyrosine residues to be phosphorylated by the tyrosine kinase domain of the activated receptor that will attract further molecules containing SH2 domains or plekstrin homoly (PH) domains, these last will anchor IRS to phosphoinositides on the cell membrane

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Researchers coming from GLP-1 work will recognize this part of the mechanism

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Eder T, Weber A, Neuwirt H, Grunbacher G, Ploner C, Klocker H et al

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For example, when you take an oral supplement, your body absorbs the B12 through the lining of your stomach

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doi: 10.1016/B978-0-12-800100-4.00003-9

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