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Naltrexone, approved in 1984, introduced a non-opioid antagonist that blocked the effects of opioids but required full detoxification before initiation, limiting its early use

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Additional research continues to explore its role in vascularization, collagen remodeling, and coordinated cellular response mechanisms

doi: 10.1002/14651858.CD011016.pub2

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The numbers below come from two places: rodent studies scaled to a human size (allometric scaling) and several years of research community use reports