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Warning signs include persistent fatigue despite adequate sleep, cold intolerance (especially cold hands and feet), menstrual irregularity or cessation in female subjects, hair thinning or shedding, and mood disturbances (irritability, low motivation)

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Mutat Res 2015

Environmental enrichment induces neuroplastic changes in middle age female Balb/c mice and increases the hippocampal levels of BDNF, p-Akt and p-MAPK1/2

Modulates the nitric oxide (NO) system to support endothelial function

This limits the stress occurring on specific muscles as different activities use muscles in different ways