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The study reported that patients treated with a combination of thiopurine and allopurinol were more likely to achieve the desired 6-TGN levels than those receiving the split-dose regimen ( Other Factors Influencing Thiopurine Treatment Outcome Before prescribing thiopurines to the patients, several factors should be considered, as they can affect the outcome of thiopurine therapy

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Biointerface Res Appl Chem 12(2):26292645 Aguilar-Toal JE, Garcia-Varela R, Garcia HS, Mata-Haro V, Gonzlez-Crdova AF, Vallejo-Cordoba B, Hernndez-Mendoza A (2018) Postbiotics: an evolving term within the functional foods field