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Kurutas Nutr J 15:122 Laua A, Villeneuvea NF, Suna Z, Wong b PK, Zhang DD (2008) Dual roles of Nrf2 in cancer

This might be associated with a metabolic imbalance, resulting in the accumulation of reactive species, which may be responsible for the premature ageing and tissue damage found in Down syndrome

Hibiscus is another option

6 Neuroinflammation TBI triggers a complex array of immune and inflammatory responses in tissues, resembling the reactions observed in ischemia/reperfusion injury

Bull Exp Biol Med 2021;171:17989

Suppression of the gut microbiome ameliorates age-related arterial dysfunction and oxidative stress in mice