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Intramuscular (IM) B12 injections using hydroxocobalamin, the preferred licensed form in the UK are recommended when: Oral supplementation has failed to correct a documented deficiency The patient has difficulty adhering to daily oral regimens Serum B12 levels remain persistently low despite adequate oral dosing There is clinical evidence of neurological or haematological complications In line with BNF guidance, the standard IM regimen for confirmed deficiency without neurological involvement is a loading course of 1 mg hydroxocobalamin on alternate days for two weeks , followed by maintenance of 1 mg every three months

Research on B12 Levels in Different Types of Thalassemia Studies have found that B12 deficiency is common in thalassemia patients, but more so in certain types

Neurological symptoms caused by long-term deficiency may take several weeks to months to fully improve

Exceptionally potent cross-reactive neutralization of Nipah and Hendra viruses by a human monoclonal antibody

Chronic treatment should be done with an oral preparation in patients with normal intestinal absorption