LoGuidice A, Wallace BD, Bendel L, Redinbo MR, Boelsterli UA
10.3389/fphar.2021.772418 104
In this article, we review efforts to develop new drugs targeting these processes, including agents that reactivate fetal haemoglobin, anti-sickling agents, anti-adhesion agents, modulators of ischaemiareperfusion and oxidative stress, agents that counteract free haemoglobin and haem, anti-inflammatory agents, anti-thrombotic agents and anti-platelet agents
The former increased hsCRP more than the latter
The KTTKS amino sequence is then attached for better oil solubility and skin penetration to palmitic acid and BOOM
The peptide's short plasma half-life (estimated at several minutes for the native peptide) likely limits systemic accumulation