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;4(24) Clemmensen C, Smajilovic S, Smith EP, Woods SC, Brauner-Osborne H, Seeley RJ et al (2013) Oral L-arginine stimulates GLP-1 secretion to improve glucose tolerance in male mice

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DSIP (delta sleep-inducing peptide) was first isolated from rabbit cerebral venous blood in 1974 and has accumulated a small but published clinical-trial base most notably a 1992 Schneider-Helmert study showing improved sleep with DSIP infusion in chronic insomniacs over 7 successive nights and earlier studies showing improved sleep duration in middle-aged chronic insomniacs

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The caloric deficit necessary for significant fat loss also creates conditions where muscle tissue becomes vulnerable to catabolism

C1q, the recognition subcomponent of the classical pathway of complement, drives microglial activation