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Plant Cell 31 (1), 189209

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Ralston AC, Webb RK, Runciman WB

also known as xCT) and the selenium-dependent hydroperoxidase glutathione peroxidase 4 (GPX4) are the most potent antioxidant hubs protecting against ferroptosis [35, 36], with the cystine/glutamate antiporter subunit SLC7A11 importing cysteine to synthesize glutathione (GSH), a critical cofactor to multiple antioxidant proteins, including GPX4, thereby detoxifying lipid peroxides and suppressing ferroptosis [33, 37]

These alternatively activated macrophages release high levels of pro-metastatic cytokines in the circulation of HCC patients, such as IL-6, IL-1, and TNF- (Ataseven et al., 2006)

Y.De RaeymaeckerJ.TameJ.ZhangK.De MaeyerM.et al (2014)