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During the progression of aging-associated degeneration diseases, altered cell fate of adult stem cells, or dysfunction of terminally differentiated mature cells occurs, which may result from the changed ECM niche modified with aging-related proteins and reduced expression of ECM-synthesis-associated proteins (Goupille et al., 1998

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Superoxide radical and hydrogen peroxide are generated when the cell is exposed to stressors such as certain drugs, radiation or normal mitochondrial respiration

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Similar findings were reported by Zhang and Zheng [30] that exogenous O 2 significantly improved the percentage of human sperm that underwent capacitation (from 14.01.3 to 23.22.5) and acrosome reaction (from 4.5%1.1% to 16%2.0%, respectively)