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The extensive changes in the levels of these cytokines and chemokines are most likely due to the imbalance in the Th1/Th17 and Treg cell subsets in patients with MS

Matrix metalloproteinase (MMP) activities are tightly regulated in the BBB and increased levels can cause leakiness, while reduced levels can affect angiogenesis and plasticity (Huang et al

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Lochyski, T

Additionally, ICP34.5 impedes autophagic processes through Beclin binding interactions specifically targeting Beclin-1 (Atg6) (35)

25,26 Furthermore, a polymorphism of the DHFR enzyme resulting in a 19bp deletion within the site of a key regulatory sequence has been theorized to exhibit negative effects on the expression and activity of this enzyme