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In addition, endothelial dysfunction and initiation of atherogenesis are known to trigger by activating the nuclear factor-B (NF-B) signaling pathway and NLRP3 (NOD-like receptor protein 3 or NLR family pyrin domain containing 3) inflammasome pathway in endothelial cells both in vitro and in vivo (Seldin et al., 2016

Early studies suggest potential benefits in conditions involving impaired intestinal motility or altered gut hormone signaling, including metabolic disorders and certain gastrointestinal diseases

Whether these distinct forms of cell death related to distinct pathologies, CNS regions, age, or subpopulations of OLs remains to be defined

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doi:10.1021/es203529z WHO (2016) | Comprehensive mental health action plan 20132020

Lundgren et al