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Historically, the obesity pharmacotherapy literature notes early trial signals and also that development was terminated after failure to show meaningful weight loss in a larger, longer trial (as summarized in a peer-reviewed review discussing a 12-week signal and a later 24-week negative result)

Lin, C.L

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EMBO Reports 26, 13441366

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The NHS II observed elevated risk with 20 years of NSW, while NHS I and payroll-based cohorts were mixed or null 295,296,297,298